منابع مشابه
Localized reduction of atherosclerosis in von Willebrand factor-deficient mice.
To examine the role of the platelet adhesion molecule von Willebrand factor (vWf) in atherogenesis, vWf-deficient mice (vWf-/-) were bred with mice lacking the low-density lipoprotein receptor (LDLR-/-) on a C57BL/6J background. LDLR-/-vWf+/+ and LDLR-/-vWf-/- mice were placed on a diet rich in saturated fat and cholesterol for different lengths of time. The atherogenic diet stimulated leukocyt...
متن کاملCorrection of bleeding symptoms in von Willebrand factor-deficient mice by liver-expressed von Willebrand factor mutants.
OBJECTIVE von Willebrand Factor (vWF) structure-function relationship has been studied only in vitro. To investigate the physiological importance of particular vWF domains, we have introduced mutations into murine vWF (mvWF) cDNA inhibiting vWF binding to glycoprotein (Gp) Ib, GpIIbIIIa, and to fibrillar collagen. METHODS AND RESULTS We delivered wild-type (WT) or mutant mvWF cDNA into vWF-de...
متن کاملMice deficient in the anti-haemophilic coagulation factor VIII show increased von Willebrand factor plasma levels
Von Willebrand factor (VWF) is the carrier protein of the anti-haemophilic Factor VIII (FVIII) in plasma. It has been reported that the infusion of FVIII concentrate in haemophilia A patients results in lowered VWF plasma levels. However, the impact of F8-deficiency on VWF plasma levels in F8-/y mice is unresolved. In order to avoid confounding variables, we back-crossed F8-deficient mice onto ...
متن کاملHEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Localized reduction of atherosclerosis in von Willebrand factor–deficient mice
To examine the role of the platelet adhesion molecule von Willebrand factor (vWf) in atherogenesis, vWf-deficient mice (vWf2/2) were bred with mice lacking the low-density lipoprotein receptor (LDLR2/2) on a C57BL/6J background. LDLR2/2vWf1/1 and LDLR2/2vWf2/2 mice were placed on a diet rich in saturated fat and cholesterol for different lengths of time. The atherogenic diet stimulated leukocyt...
متن کاملZebrafish von Willebrand factor.
von Willebrand factor (vWF) is a large protein involved in primary hemostasis. A dysfunction in this protein or an insufficient production of the protein leads to improper platelet adhesion/aggregation, resulting in a bleeding phenotype known as von Willebrand disease (vWD). To gain a better understanding of vWF interactions in vivo, the use of zebrafish as a model is ideal because of the trans...
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ژورنال
عنوان ژورنال: Japanese Journal of Thrombosis and Hemostasis
سال: 1999
ISSN: 1880-8808,0915-7441
DOI: 10.2491/jjsth.10.212